Bilirubin ( BR) is a red-orange compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates. This catabolism is a necessary process in the body's clearance of waste products that arise from the destruction of aged or abnormal red blood cells. In the first step of bilirubin synthesis, the heme molecule is stripped.
bilirubin: [noun] a reddish-yellow water-insoluble pigment C33H36N4O6 that is formed by the breakdown of heme, is excreted in a water-soluble form by liver cells into bile, and occurs in blood and urine especially in diseased states — see jaundice.
Bilirubin is an important metabolite of heme (ferroprotoporphyrin IX), a coordination complex that serves to coordinate iron in various proteins. It is a potentially toxic substance. However, the body has developed mechanisms for its safe detoxification and disposition. Bilirubin and its metabolites also provide the distinctive yellow color to bile and stool and a lesser degree, urine. This.
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